What Makes Us Different?
We use TruNano Technology to create Nanoemulsions that have approximately 10 times lower surfactant amounts than microemulsions or liposomes:
- Highest bioavailability
- Low viscosity / water soluble
- Long-term kinetic stability
- Easily mixed into food or beverage
- Best choice for most Nano applications
Current Trends on Cannabidiol Delivery Systems
Research Abstract
Introduction: Cannabidiol (CBD), a phytocannabinoid from Cannabis sativa, has several therapeutic properties. However, its high lipophilicity, metabolization, and instability impair its bioavailability and translational use in clinical settings. Several advanced drug delivery systems (ADDSs) have been evaluated as CBD carriers to overcome these drawbacks. These systems can improve the CBD dissolution profile, protect it against metabolization, and produce a site-specific release, increasing its bioavailability and making CBD administration clinically effective. (ÍMM, 2021).
Nano Emulsification is the State-of-the-Art for Advanced Drug Delivery Systems (ADDSs)
A new technology is entering the CBD space to help solve common problems faced by consumers. Consistency in dosing, how cannabinoids (CBD, CBG, CBN) are absorbed into our bodies, and the effectiveness of various delivery methods are just a few of the improvements Nanoemulsion technology is bringing to CBD products.
Nanoemulsions are emulsions with narrow droplet size distributions centered below approximately 100 nm. Nanoemulsion-based formulations in which all droplets are smaller than 30 nm are optically translucent, achieving a progressively higher degree of clarity as the droplet sizes are diminished. These formulations have several attractive properties, including low viscosity, high interfacial surface area, and long-term kinetic stability. Nanoemulsions are made using significantly (about 10 times) lower surfactant amounts than microemulsions or liposomes. They are completely water-soluble and can be easily mixed into any food or beverage.
In simpler terms, Nanoemulsions are smaller, water-soluble particles that breakdown quickly and absorb into the bloodstream faster. This means increased bioavailability using far less product. Nanoemulsion particles are small enough to bypass the tissue layers and more easily enter the bloodstream. They can also be absorbed through the skin, opening us up to even more potential delivery methods. Bioavailability is increased to nearly 95%.
Bioavailability is an important concept in the pharmacology of CBD and how it affects us. Bioavailability is the degree and rate at which a substance is absorbed into our bodies. In order for the CBD to work, it has to reach its intended destination. Increasing the bioavailability of CBD has been a challenge. CBD onset times and absorption rates can vary greatly between methods such as inhalation, oral, topical, and sublingual. Nanoemulsion technology allows for faster onset times and increased absorption rates meaning consumers will get faster relief using less product. (Definition, 2023).
Citations
Ramalho ÍMM, Pereira DT, Galvão GBL, Freire DT, Amaral-Machado L, Alencar ÉDN, Egito ESTD. Current trends on cannabidiol delivery systems: where are we and where are we going? Expert Opin Drug Deliv. 2021 Nov;18(11):1577-1587. doi: 10.1080/17425247.2021.1952978. Epub 2021 Jul 19. PMID: 34253133.